Back to results
US 2013/0252980 A1Published application
Novel gpr 119 agonists
AssigneeCadila Healthcare Limited
InventorsHarikishore Pingali, Pandurang Zaware
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel GPR 119 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation.
Claims15
Compounds of the general formula (I),
- their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them wherein “R1” represents H, optionally substituted groups selected from linear or branched (C1-C6), alkyl, haloalkyl, (C1-C6)alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroarylalkyl, alkylsulfonyl, arylsulfonyl, or the groups represented by (CH2)mCO2R4, (CH2)mCOR4 or (CH2)mCONH2 wherein R4 at each occurrence independently represents H, groups selected from linear or branched (C1-C6)alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl and m=0 to 3;
- “R2” represents H, cyano, nitro, formyl, linear or branched (C1-C6) alkyl, (C1-C6) alkoxy groups;
- “R3” represents optionally substituted groups selected from linear or branched (C1-C6)alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroaralkyl or the groups represented by C(O)OR5, C(O)R5, and SO2R5 wherein R5 at each occurrence independently represents H or optionally substituted groups selected from linear or branched (C1-C6)alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, hererocyclylalkyl, heteroaryl, heteroaralkyl groups;
- “n” represents an integer from 0 to 3;
- “A” represents
- wherein “p” represents integers from 1 to 3;
- “X” represents O, S.
4 more elements
Dependencies are inferred from the claim text.