Substituted piperidines

A method of prophylaxis of thromboembolic disorders in humans and animals comprising administering to the human or animal an anticoagulatory amount of a compound of formula (I):

• in which
• R1 is trifluoromethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, difluoromethoxy, trifluoromethoxy or ethyl,
• R2 is 2-hydroxyeth-1-yl, 2-methoxyeth-1-yl, 2-ethoxyeth-1-yl, cyclopropyl or 1-methoxycycloprop-1-yl,
• R3 is a group of the formula
• where
• * is the point of attachment to the carbonyl group, or a salt thereof.

A method of prophylaxis of a pulmonary disorder comprising administering to a patient in need thereof a therapeutically effective, anticoagulatory, amount of a compound of formula (I):

• in which
• R1 is trifluoromethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, difluoromethoxy, trifluoromethoxy or ethyl,
• R2 is 2-hydroxyeth-1-yl, 2-methoxyeth-1-yl, 2-ethoxyeth-1-yl, cyclopropyl or 1-methoxycycloprop-1-yl,
• R3 is a group of the formula
• where
• * is the point of attachment to the carbonyl group,
• or a salt thereof.