Synthetic bile acid compositions and methods
AssigneeKythera Biopharmaceuticals, Inc.
InventorsRobert M. Moriarty, Nathaniel E. David, Nadir Ahmeduddin Mahmood
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Abstract
Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.
Claims15
A compound that is deoxycholic acid (DCA) or a pharmaceutically acceptable salt thereof:
- wherein said DCA has a 14C content of less than 1 ppt.
A compound that is deoxycholic acid (DCA) or a pharmaceutically acceptable salt thereof:
- wherein said DCA has a 14C content of less than 0.86 ppt.
A compound that is deoxycholic acid (DCA) or a pharmaceutically acceptable salt thereof:
- wherein said DCA has a 14C content of greater than 1 ppt.
A compound that is a synthetic deoxycholic acid (DCA) or a pharmaceutically acceptable salt thereof:
- wherein said DCA comprises a synthetic side chain:
- and has a 14C content of 1 ppt.
A method for determining whether a sample of deoxycholic acid was prepared synthetically, which method comprises:
- a) assaying a sample of deoxycholic acid or a salt thereof for its fossil carbon or 14C content;
- b) comparing the fossil carbon or 14C content of the sample against the fossil carbon or 14C content of naturally occurring deoxycholic acid to determine whether the sample was prepared synthetically.
Dependencies are inferred from the claim text.