18-Membered Macrocycles and Analogs Thereof
AssigneeOptimer Pharmaceuticals, Inc.
InventorsYoue-Kong Shue, Chan-Kou Hwang, Yu-Hung Chiu, Alex Romero, Farah Babakhani, Pamela Sears, Franklin Okumu
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Abstract
The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
Claims16
A substantially stereomerically pure compound having the formula:
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
A composition comprising a substantially stereomerically pure compound having the formula:
- or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
Dependencies are inferred from the claim text.