Peptide compound useful for inhibiting amyloid plaque formation
AssigneeKimonella Ventures Ltd.
InventorsOleg Mediannikov, Alexander Morozov
Life of this patent
Estimating the term…
Abstract
A peptide compound of the following general formula (I) or (II): Ra—R1—R2—R3—R4—Rb (I) or Ra—R4—R3—R2—R1—Rb (II) wherein, R1 is a residue of amino acid H, R or K; R2 is a residue of amino acid A; R3 is a residue of amino acid E or D; R4 is a residue of amino acid E or D, Ra represents the N-terminal primary amine functions of the amino acid R1 or R4, either free or substituted with a protective group, Rb represents the hydroxyl function of the C-terminal carboxyl group of the amino acid R1 or R4, either free or substituted with a protective group.
Claims17
A peptide compound of the following general formula (I) or (II):
- Ra—R1—R2—R3—R4—Rb (I)
- or
- Ra—R4—R3—R2—R1—Rb (II)
- wherein,
- Ra represents the N-terminal primary amine function of the amino acid R1 or R4, either free or substituted with a protective group, and
- Rb represents the hydroxyl function of the C-terminal carboxyl group of the amino acid R1 or R4, either free or substituted with a protective group, and
- R1—R2—R3—R4 or R4—R3—R2—R1 represent HADD, KADD, DDAK, RADD, DDAR, KAED, DEAK, RAED, DEAR, HADE, EDAH, KADE, EDAK, RADE, EDAR, HAEE, EEAH, KAEE, EEAK, RAEE and EEAR.
7-8. (canceled)
10-12. (canceled)
Dependencies are inferred from the claim text.