Therapeutically Active Alpha-MSH Analogues
AssigneeAbbVie Inc.
InventorsThomas E.N. JONASSEN, Soren NIELSEN, Jorgen FROKIAER, Bjarne Due LARSEN
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AssigneeAbbVie Inc.
InventorsThomas E.N. JONASSEN, Soren NIELSEN, Jorgen FROKIAER, Bjarne Due LARSEN
Estimating the term…
The invention describes peptide analogues of α-melanocyte-stimulating hormone (α-MSH), which possess an increased efficacy compared to the native α-MSH peptide. The α-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions compared to α-MSH. The invention further discloses use of the peptides for the manufacture of pharmaceutical compositions for the treatment or prophylaxis of a condition in the tissue of one or more organs of a mammal, and moreover pharmaceutical compositions.
A peptide comprising SEQ ID NO:1, wherein said SEQ ID NO:1 is N-terminally acetylated and C-terminally amidated.
Dependencies are inferred from the claim text.