US 2013/0252880 A1 · Dendrimeric Peptides, Pharmaceutical Compositions And Methods Of Using The same

Abstract

Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.

Claims85

Dependent claims

An antimicrobial peptide according to formula (I):

wherein
each L1 is —(CH2)n-;
n is 2, 3, 4 or 5;
each L2 is a dipeptide or a tripeptide linker;
and Z is selected from substituted or unsubstituted amino, hydroxy, substituted or unsubstituted alkoxy, and substituted or unsubstituted aryloxy;
or a pharmaceutically acceptable salt, solvate or prodrug thereof;
and stereoisomers, isotopic variants and tautomers thereof.

4 more elements

Dependencies are inferred from the claim text.

Dendrimeric Peptides, Pharmaceutical Compositions And Methods Of Using The same

Life of this patent

Dendrimeric Peptides, Pharmaceutical Compositions And Methods Of Using The same

Life of this patent

Abstract

Claims85