Compositions and method for promoting musculoskeletal repair
AssigneeThe Cleveland Clinic Foundation
InventorMarc S. Penn
Life of this patent
Estimating the term…
Abstract
A method of treating a musculoskeletal injury in a subject includes administering directly to a site of the musculoskeletal injury or to an area proximate the musculoskeletal injury an amount of SDF-1, MCP-3, or combinations thereof effective to promote repair of the musculoskeletal injury of the subject and recruit connective tissue progenitor cells to the site of the musculoskeletal injury.
Claims26
A method of treating a musculoskeletal injury in a subject, comprising:
- administering directly to a site of the musculoskeletal injury or to an area proximate the musculoskeletal injury an amount of SDF-1, MCP-3, or combinations thereof effective to promote repair of the musculoskeletal injury of the subject and recruit connective tissue progenitor cells to the site of the musculoskeletal injury.
A method of treating a musculoskeletal injury in a subject, comprising:
- administering directly to a site of the musculoskeletal injury or to an area proximate the musculoskeletal injury an amount of SDF-1 and MCP-3 effective to promote repair of the musculoskeletal injury of the subject and recruit connective tissue progenitor cells to the site of the musculoskeletal injury.
A bone graft or bone graft substitute for treating a musculoskeletal injury, the bone graft or bone graft substitute comprising:
- an amount of SDF-1 and/or MCP-3 effective to promote repair of the musculoskeletal injury of the subject and recruit connective tissue progenitor cells to the site of the musculoskeletal injury;
- and
- an osteoconductive matrix.
Dependencies are inferred from the claim text.