Arrayed detector system for measurement of anti-viral immune response

A detection system comprising:

• an arrayed imaging reflectometry (AIR) sensor chip suitable for the detection of antiviral immune responses comprising:
• a multilayer substrate comprising a surface comprising virus-like particles (VLPs) or viral capsid (CA) fragments from different viral strains or isolates, wherein said VLPs or CA fragments are covalently attached to the surface at different locations and retain conformational epitopes that are capable of binding to antiviral antibodies;
• a light source that is positioned to illuminate the sensor chip;
• and
• a detector that is positioned to detect light reflected from the surface of the chip and thereby determine whether an antibody binds to the VLPs or CA fragments, wherein a destructive interference of polarized light illuminating the surface occurs in an absence of antibody binding and antibody binding produces a change in reflectance detectable by the detector.