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US 2013/0252833 A1Published application
Drg11-responsive (dragon) gene and uses thereof
OwnerClifford J. Woolf, Tarek A. Samadinventors
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Abstract
This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-β signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy.
Claims2
A method for identifying a compound that modulates a TGF-β signaling pathway, said method comprising the steps of:
- a. providing a sample comprising a DRAGON protein and a TGF-β signaling pathway member;
- b. contacting said sample with a candidate compound;
- and
- c. assessing the binding of said DRAGON protein to said TGF-β signaling pathway member in said sample in the presence of said candidate compound relative to binding in the absence of said candidate compound, wherein a compound that modulates binding of said DRAGON protein to said TGF-β signaling pathway member is identified as a compound that modulates a TGF-β signaling pathway.
1 more element
2-41. (canceled)
Dependencies are inferred from the claim text.