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OwnerFrank Weber, Bertram Müller-Myhsok +2inventors
InventorsFrank Weber, Bertram Müller-Myhsok, Florian Holsboer, Bernhard Hemmer
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The present invention relates to a method of diagnosing a predisposition of a multiple sclerosis patient to become less susceptible or resistant to treatment with interferon β, said method comprising determining in a sample obtained from said patient the presence of one or more SNP(s) selected from the group consisting of SNPs defined by the sequences of SEQ ID NOs 12, 17, 2, 3, 5, 7, 8, 1, 4, 6, 9, 10, 11, 13, 14, 15 and 16, wherein the presence of one or more of said SNP(s) in said sample is indicative for said predisposition.
A method of diagnosing a predisposition of a multiple sclerosis patient to become less susceptible or resistant to treatment with interferon β, said method comprising determining in a sample obtained from said patient the presence of one or more SNP(s) selected from the group consisting of SNPs defined by the sequences of SEQ ID NOs 12, 17, 2, 3, 5, 7, 8, 1, 4, 6, 9, 10, 11, 13, 14, 15 and 16,
A method of diagnosing a predisposition of a multiple sclerosis patient for developing neutralizing antibodies against interferon-β, said method comprising determining in a sample obtained from said patient the presence of one or more SNP(s) selected from the group consisting of SNPs defined by the sequences of SEQ ID NOs 12, 17, 2, 3, 5, 7, 8, 1, 4, 6, 9, 10, 11, 13, 14, 15 and 16,
A method of diagnosing a predisposition of a multiple sclerosis patient for developing high antibody titers against interferon-β, said method comprising assessing in a sample obtained from said patient the presence of one or more SNP(s) selected from a subgroup consisting of SNPs defined by the sequences of SEQ ID NOs 12, 17, 3, 5, 7, 8, 6, 9, 13 and 16;
Dependencies are inferred from the claim text.