Compositions and methods for modulating metabolism
OwnerJames Elliott Bradner, Jonathan Brown +1inventors
InventorsJames Elliott Bradner, Jonathan Brown, Jorge Plutzky
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Abstract
The invention provides compositions comprising an effective amount of an agent that inhibits a BET protein (e.g., Brd2, Brd3, Brd4), and methods of using such compositions for treating or preventing metabolic syndrome, obesity, type II diabetes, insulin resistance, and related disorders characterized by undesirable alterations in metabolism or fat accumulation.
Claims21
A method of inhibiting adipogenesis, the method comprising contacting an adipocyte or pre-adipocyte with an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein.
A method of inhibiting adipocyte biological function, the method comprising contacting an adipocyte with an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein.
A method for treating or preventing metabolic syndrome in a subject, the method comprising administering to the subject an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein, thereby treating or preventing metabolic syndrome in the subject.
A method for treating or preventing obesity or weight gain in a subject, the method comprising administering to the subject an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein, thereby treating or preventing obesity or weight gain in the subject.
A method of inhibiting hepatic steatosis in a subject, the method comprising administering to the subject an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein, thereby inhibiting hepatic steatosis.
A method of reducing subcutaneous fat or visceral fat in a subject, the method comprising administering to the subject an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein, thereby reducing subcutaneous fat or visceral fat in the subject.
A method of inhibiting food intake or increasing metabolism in a subject, the method comprising administering to the subject an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein, thereby inhibiting food intake or increasing metabolism in the subject.
A method of protecting against insulin resistance in a subject, the method comprising administering to the subject an effective amount of an agent that inhibits a bromodomain and extra-terminal (BET) protein, thereby protecting against insulin resistance in the subject.
Dependencies are inferred from the claim text.