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US 2013/0252277 A1Published application
Method of operation of fermentation of carbon monoxide containing gaseous substrate
AssigneeIneos Bio SA
InventorsRyan Senaratne, Brandon Beard
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Abstract
The present disclosure provides methods of gaseous substrate fermentation comprising: adding gaseous substrate into an aqueous medium in a bioreactor. The methods of the present disclosure comprise: measuring cell density; adjusting input of gaseous substrate to increase cell density; changing specific CO uptake in predetermined amounts.
Claims18
A process of producing one or more alcohols from a gaseous substrate, comprising:
- fermenting a gaseous substrate comprising carbon monoxide (CO) into an aqueous medium in a bioreactor;
- said process comprising increasing cell density by adjusting specific CO uptake in said aqueous medium.
A method gaseous substrate fermentation comprising:
- adding gaseous substrate comprising carbon monoxide into an aqueous medium in a bioreactor;
- said method comprising selecting target specific CO uptake;
- adjusting flow of gaseous substrate such that specific CO uptake equals said target specific CO uptake in a range of about 0.01 to about 10 mmol/min/gram dry cell.
A method gaseous substrate fermentation comprising:
- adding gaseous substrate comprising carbon monoxide into an aqueous medium in a bioreactor;
- said method comprising the steps of selecting target specific CO uptake in a range of about 0.01 to about 10 mmol/min/gram dry cell, adjusting flow of gaseous substrate such that specific CO uptake equals said target specific CO uptake;
- repeating said steps until attaining desired cell density in a range of about 0.1 to about 15 g/L;
- upon attaining said desired cell density converting to continuous mode of operation.
1 more element
A method gaseous substrate fermentation comprising:
- adding gaseous substrate comprising carbon monoxide into an aqueous medium in a bioreactor;
- said method comprising selecting target specific CO uptake;
- adjusting flow of gaseous substrate such that specific CO uptake equals said target specific CO uptake in a range of about 0.01 to about 10 mmol/min/gram dry cell.
A method gaseous substrate fermentation comprising:
- adding gaseous substrate comprising carbon monoxide into an aqueous medium in a bioreactor;
- said method comprising the steps of selecting target specific CO uptake in a range of about 0.01 to about 10 mmol/min/gram dry cell, adjusting flow of gaseous substrate such that specific CO uptake equals said target specific CO uptake;
- repeating said steps until attaining desired cell density in a range of about 0.1 to about 15 g/L;
- upon attaining said desired cell density converting to continuous mode of operation.
1 more element
Dependencies are inferred from the claim text.