Biologic Machines for the Detection of Biomolecules
AssigneeLaboratory Corporation of America Holdings
InventorsJeff Albrecht, Andrew J. Conrad
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Abstract
Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.
Claims26
A method for detecting a microorganism comprising the steps of:
- infecting the isolated microorganism with an infectious agent that can reproduce in the microorganism so as to produce progeny infectious agents;
- allowing the infected microorganism to release the progeny infectious agents;
- and
- detecting the progeny infectious agents, wherein detection of the progeny infectious agents indicates that the microorganism is present in the sample.
A device for detecting a microorganism comprising:
- a component for containing a sample comprising a microorganism;
- a component for adding an infectious agent that can infect the microorganism so as to generate progeny infectious agents;
- and
- a component for detecting the progeny infectious agents, wherein detection of the infectious agents indicates that the microorganism is present in the sample.
A device for detection of a biomolecule comprising:
- a container for holding at least one recognition partner for the biomolecule, wherein the recognition partner undergoes a measurable physical or chemical transformation upon interaction with the biomolecule;
- and
- a unit that detects the measurable physical or chemical transformation.
A system for detection of a biomolecule comprising:
- a container for holding at least one recognition partner for the biomolecule, wherein the recognition partner undergoes a measurable physical or chemical transformation upon interaction with the biomolecule;
- a unit that detects the measurable physical or chemical transformation;
- and
- a computer.
A system for detection of a microorganism comprising:
- a component for containing a sample comprising a microorganism;
- a component for adding an infectious agent that can infect the microorganism so as to generate progeny infectious agents;
- a component for detecting the progeny infectious agents, wherein detection of the infectious agents indicates that the microorganism is present in the sample;
- and
- a computer.
A method for measuring a biomolecule using a device for detection of a biomolecule comprising:
- adding a sample comprising a biomolecule of interest to a container for holding at least one recognition partner for the biomolecule, wherein the recognition partner undergoes a measurable physical or chemical transformation upon interaction with the biomolecule;
- and
- measuring the physical or chemical transformation using a unit that detects the measurable physical or chemical transformation.
Dependencies are inferred from the claim text.