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US 2013/0240449 A1Published application
Device for material purification
AssigneeAdvion Inc.
InventorLee Collier
Life of this patent
Estimating the term…
Abstract
Systems and methods for purification of radiotracers and non-radioactive materials produced by both microfluidic, conventional, semi-automated and manual synthesis systems are described herein.
Claims17
A compound purification system, comprising:
- a liquid storage device for storing a non-purified reaction product;
- a first multiport valve having:
- a first port of the first multiport valve configured to be connected to a water or buffer supply,
- a second port of the first multiport valve configured to be connected to a device supplying a reaction product;
- a third port of the first multiport valve connected to an input of the liquid storage device,
- a fourth port of the first multiport valve connected to an output of the liquid storage device;
- and
- a fifth port providing an output from the first multiport valve;
- a pre-concentration column;
- a purification column,
- a second multiport valve having:
- a first port of the second multiport valve connected to the output from the first multiport valve and configured to receive the non-purified reaction product from the first multiport valve;
- a second port of the second multiport valve connected to an input of the pre-concentration column;
- a third port of the second multiport valve connected to an output of the pre-concentration column;
- and
- a fourth port of the second multiport valve connected to an input of the purification column.
13 more elements
A compound purification system, comprising:
- a multi-position multi-port valve;
- a pre-concentration column having an input connected to a first port of the valve and an output connected to a second port of the valve;
- a purification column having an input connected to a third port of the valve and an output;
- wherein, in a first position, the multi-port valve is configured to provide a fluid path between an input port and a waste port such that during use a liquid can flow from the input port, across the pre-concentration column and to the waste port and, in a second position. the multi-port valve is configured to provide a fluid path between the pre-concentration column and purification column such that during use a liquid can flow from the pre-concentration column to the purification column.
1 more element
A method comprising:
- positioning a multiport valve in a first position, the multiport valve having ports connected to a pre-concentration column, a purification column, a waste receptacle, and a storage receptacle;
- while in the first position, pushing a liquid across the pre-concentration column to a waste receptacle such that impurities not trapped by the pre-concentration column flow to the waste receptacle;
- subsequent to pushing the liquid across the pre-concentration column, positioning the multiport valve in a second position that is different from the first position;
- while in the second position, eluting liquid from the pre-concentration column onto the purification column.
1 more element
Dependencies are inferred from the claim text.