Estrogen receptor modulators and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt, or N-oxide thereof:

• wherein,
• ring A is indanyl, indenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl, or 8-, 9- or 10-membered bicyclic heterocycle;
• ring B is phenyl, indanyl, indenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl or 8-, 9- or 10-membered bicyclic heterocycle;
• ring C is phenyl, indanyl, indenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl or 8-, 9- or 10-membered bicyclic heterocycle;
• R1 is Y, —X—C1-C6alkylene-Y, —C1-C6alkylene-Y, —C2-C6alkynylene-Y, —C(R6)═C(R7)—Y, —X—C1-C6alkynyl-Y, —X—C3-C6cycloalkyl-Y or C3-C6cycloalkyl-Y;
• X is NR8, O, S, S(═O) or S(═O)2;
• Y is —C(═O)—Z, tetrazolyl, carboxylic acid bioisostere, optionally substituted piperidinyl, optionally substituted pyrrolidinyl, —NR8R8′, -AR—OH, —SO3H, —SO2NHR9, and —P(═O)(OH)2 wherein AR is phenyl or monocyclic heteroaryl;
• Z is —OH, —OR10, —NR8R8′, —NR8S(═O)2R10, —NHOH or —NR8OR10;
• R2 is halogen, CN, NO2, —SR9, —S(═O)R10, —S(═O)2R10, —NHS(═O)2R10, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, C3-C6cycloalkyl, —C1-C4alkylene-W, —C1-C4fluoroalkylene-W, —C3-C6cycloalkylene-W;
• W is hydroxy, halogen, CN, NO2, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, and C3-C6cycloalkyl;
• each R3, R4, R5 is independently selected from H, halogen, —NO2, —NR8R8′, —CN, —OH, —OR9, —SR9, —S(═O)R10, —S(═O)2R10, —NHS (═)2R10, —S(═O)2N(R9)2, —C(═O)R10, —OC(═O)R10, —CO2R9, —OCO2R10, —C(═O)N(R9)2, —OC(═O)N(R9)2, —NR9C(═O)N(R9)2, —NR9C(═O)R10, —NR9C(═O)OR10, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkoxy, substituted or unsubstituted C1-C6alkoxy, substituted or unsubstituted phenyl and substituted or unsubstituted monocyclic heteroaryl;
• R6 and R7 is independently H, OR9, NR8R8′, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, —X—C1-C6alkyl, —X—C2-C6alkenyl, —X—C2-C6alkynyl, or halogen;
• R8 and R8′ is independently H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, or substituted or unsubstituted benzyl;
• each R9 is independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted benzyl;
• each R10 is independently selected from substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted benzyl;
• m is 0, 1, 2, 3, or 4;
• n is 0, 1, 2, 3, or 4;
• and
• p is 0, 1, 2, 3, or 4.