Method of pre-treating an adsorbent for a chromatographic separation
AssigneeNordion (Canada) Inc.
InventorSteve OELSNER
Life of this patent
Estimating the term…
Abstract
A method of treating an adsorbent for a chromatographic separation. The method involves sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide and washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter to produce a treated adsorbent. The treated adsorbent can be used in a method of isolating a daughter radioisotope from a daughter radioisotope that is produced from the parent radioisotope by radioactive decay.
Claims40
A method of treating an adsorbent for a chromatographic separation, comprising:
- sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide, and
- washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter, thereby producing a washed, treated adsorbent.
A method of isolating a daughter radioisotope from a parent radioisotope, the daughter radioisotope produced from the parent radioisotope by radioactive decay, the method comprising:
- adsorbing the parent radioisotope onto particles of an inorganic metal oxide having a smoothened surface to produce inorganic metal oxide particles comprising adsorbed parent radioisotope;
- allowing a portion of the parent radioisotope to decay to the daughter radioisotope, and
- eluting a solution of the daughter radioisotope from the inorganic metal oxide particles comprising adsorbed parent radioisotope, thereby isolating the daughter radioisotope from the parent radioisotope.
-44. (canceled)
A method of isolating a compound of interest from a crude sample, comprising:
- sonicating particles of an inorganic metal oxide having fragile edges in the absence of any alkylating or acylating agent to form smoothened particles of the inorganic metal oxide;
- washing the smoothened particles of the inorganic metal oxide to remove fine particulate matter, and
- using the washed, smoothened particles of the inorganic metal oxide to isolate the compound of interest.
(canceled)
A composition comprising irregularly-shaped particles of an inorganic oxide having a smoothened surface.
A chromatographic column for isolating a compound of interest, the chromatographic column packed with spherically-shaped or irregularly-shaped particles of an inorganic oxide having a smoothened surface, and comprising an inlet for an eluent and an outlet for an eluate.
A chromatographic column system for eluting a daughter radioisotope from a parent radioisotope, the chromatographic column packed with spherically-shaped or irregularly-shaped particles of an inorganic oxide having a smoothened surface and comprising an inlet for an eluent for eluting the daughter radioisotope from the parent radioisotope and an outlet for an eluate comprising the daughter radioisotope.
A generator for eluting a daughter radioisotope from a parent radioisotope and for collecting an eluate comprising the daughter radioisotope in a container, the system comprising:
- a housing comprising a radiation shield, the housing having a first end, a second end, and a wall extending between the first end and the second end, and the housing having both an internal volume and a surface that comprises an entry port and an exit port;
- a chromatographic column disposed within the internal volume of the housing and enclosed within the radiation shield, the chromatographic column comprising spherically-shaped or irregularly-shaped particles of an inorganic oxide having a smoothened surface, the spherically-shaped or irregularly-shaped particles of the inorganic oxide being loaded with the parent radioisotope, the chromatographic column having an inlet for an eluent for eluting the daughter radioisotope from the parent radioisotope and an outlet for the eluate comprising the daughter radioisotope;
- a first fluid conduit having an inlet and an outlet, the outlet of the first fluid conduit connected to and extending from the inlet of the chromatographic column to or through the entry port of the housing;
- a second fluid conduit having an inlet and an outlet, the inlet of the second fluid conduit connected to and extending from the outlet of the chromatographic column to or through the exit port of the housing, and
- a reservoir for holding a supply of eluent, the reservoir having an outlet in fluid communication with the inlet of the first fluid conduit and optionally an air inlet for admission of air from the atmosphere to apply pressure to eluent in the reservoir.
-66. (canceled)
Dependencies are inferred from the claim text.