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US 2013/0210816 A1Published application
Fused-imidazoyl compounds useful as antimicrobial agents
AssigneeMerck Sharp & Dohme Corp.
InventorsTin-Yau Chan, Henry M. Vaccaro
Life of this patent
Estimating the term…
Abstract
The invention relates to fused-imidazoyl compounds of Formula (I): wherein ring A, R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined herein. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and methods of using the compound of Formula (I) to treat microbial infections.
Claims16
The compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- X is selected from the group consisting of:
- (a) CH, and
- (b) N;
- Y is selected from the group consisting of:
- (a) CH, and
- (b) N;
- ring A is selected from the group consisting of:
- (a) cycloalkyl,
- (b) cycloalkenyl,
- (c) aryl,
- (d) heterocyclyl,
- (e) heterocyclenyl, and
- (f) heteroaryl,
- wherein said cycloalkyl, cycloalkenyl, aryl, heterocyclyl, heterocyclenyl, and heteroaryl is unsubstituted or substituted by at least one R2,
- wherein when each of said cycloalkyl, cycloalkenyl, aryl, heterocyclyl, heterocyclenyl, and heteroaryl, has substituents on adjacent carbon atoms, said substituents can optionally be taken together with the carbon atoms to which they are attached to form a five- or six-membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl or heteroaryl, wherein said five- or six-membered cycloalkyl, cycloalkenyl, heterocyclyl, aryl or heteroaryl is unsubstituted or substituted by at least one R2;
- each R1 is independently selected from the group consisting of:
- (a) halo,
- (b) alkyl,
- (c) alkoxyl,
- (d) —CN,
- (e) —NH2,
- (f) —N(alkyl)2,
- (g) —N(H)alkyl, and
- (h) haloalkyl;
- each R2 is independently selected from the group consisting of:
- (a) alkyl,
- (b) alkoxyl,
- (c) haloalkyl,
- (d) alkenyl,
- (e) alkynyl,
- (f) —NH2,
- (g) —N(alkyl)2,
- (h) —N(H)alkyl,
- (i) halogen,
- (j) —CN,
- (k) —OH, and
- (l) heterocyclyl;
- R3 is selected from the group consisting of:
- (a) haloalkyl,
- (b) alkoxyl,
- (c) —NH2,
- (d) —NH(alkyl),
- (e) —N(alkyl)2,
- (f) aryl,
- (g) heteroaryl, and
- (h) heteroaryl-N-oxide,
- wherein each of said aryl, heteroaryl, or heteroaryl-N-oxide is independently unsubstituted or substituted with one or more substituents independently selected from the group consisting of alkyl, haloalkyl, alkoxyl, thioalkoxyl, NO2, halo and —CN;
- R4a and R4b are independently selected from the group consisting of:
- (a) hydrogen,
- (b) alkyl, and
- (c) haloalkyl;
- R5a, R5b, R6a, R6b, R7a, R7b, R8a and R8b are independently selected from the group consisting of:
- (a) hydrogen,
- (b) alkyl, and
- (c) haloalkyl;
- R9 is selected from the group consisting of:
- (a) hydrogen,
- (b) alkyl, and
- (c) haloalkyl;
- and
- m and n independently are 0, 1, 2, 3 or 4,
- with the proviso that when Y is N, and Ring A is aryl, R3 is not
60 more elements
(canceled)
Dependencies are inferred from the claim text.