Treating hyperglycemia with 25-hydroxyvitamin d3
AssigneeDsm IP Assets B.V.
InventorsNeil Robert Buck, Wouter Claerhout, Bruno H. Leuenberger, Elisabeth Stoecklin, Kai Urban, Swen Wolfram
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Abstract
We disclose treating hyperglycemia in a human with 25-hydroxyyitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may optionally be used together with 25-hydroxy vitamin D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.
Claims5
A method of treating a human comprising administering 25-hydroxyvitamin D3 (25-OH D3) and vitamin D to the human in an amount sufficient to reduce or maintain blood plasma glucose at a level between 4 mmol/L and 7 mmol/L.
(canceled)
Use of 25-OH D3 to maintain healthy blood plasma glucose levels or to reduce blood glucose levels to healthy levels.
A composition comprising (i) vitamin D and 25-hydroxyvitamin D3 in amounts sufficient to reduce or maintain blood plasma glucose at a level between 4 mmol/L and 7 mmol/L and (ii) a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.