Preparation of low molecular weight polyornithine in high yield
AssigneeSigma-Aldrich Co.
InventorEttigounder Ponnusamy
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Abstract
The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons.
Claims20
A process for the preparation of a polyornithine polymer comprising repeating units corresponding to Formula 3 or a salt thereof and having an ornithine-basis weight average molecular weight from about 5,500 to about 12,000 Daltons, the process comprising:
- hydrolyzing a deprotected polyornithine intermediate comprising repeating units corresponding to Formula 3 or a salt thereof and having an ornithine-basis weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons, wherein
- Formula 3 has the structure:
- and n is 3.
Dependencies are inferred from the claim text.