MEDICAL DEVICES FOR DELIVERY OF siRNA
AssigneeKimberly-Clark Worldwide, Inc.
InventorRussell Frederick Ross
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Abstract
Disclosed are medical devices that incorporate siRNA. In addition to one or more siRNA constructs, devices include nanostructures fabricated on a surface to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Microneedles may be incorporated on devices. The pattern including nanostructures may be formed on the surface of the microneedles.
Claims23
A device for delivery of an siRNA construct across a dermal barrier, the device comprising:
- a microneedle and a plurality of nanostructures fabricated on a surface of the microneedle, the nanostructures being arranged in a predetermined pattern;
- and
- an siRNA construct in fluid communication with the microneedle.
A method for delivering an siRNA construct across a dermal barrier, the method comprising:
- penetrating the stratum corneum with a microneedle, the microneedle comprising a plurality of nanostructures formed on a surface of the microneedle and arranged in a pattern, the siRNA construct being in fluid communication with the microneedle, the siRNA construct being transported across the stratum corneum following penetration of the stratum corneum by the microneedle.
A method for forming a device for delivery of an siRNA construct across a dermal barrier, the method comprising:
- fabricating an array of microneedles;
- fabricating a pattern of nanostructures on a surface of at least one of the microneedles;
- associating an siRNA construct with the microneedles such that the siRNA construct is in fluid communication with the microneedles.
Dependencies are inferred from the claim text.