Intranasal Cartridge Devices

A device for dispensing a predetermined quantity of sterile fluid into a nasal passage of a user, said device comprising:

• a body, and a dispensing mechanism, the dispensing mechanism comprising:
• an activation pin extending through an opening in the body;
• a sliding member contained within the body and connected to the activation pin, wherein the sliding member comprises one or more angled cam members;
• a firing button comprising a bottom surface forming an angled cam positioned to interact with the one or more angled cams on the sliding member;
• a plunger end connected to the sliding member;
• and a chamber containing the dosage form, said dosage form comprising a first dosage chamber containing a first component of the pharmaceutical composition, a second dosage chamber containing a second component of the pharmaceutical composition, and a dispensing chamber comprising a crushable ampul or blister that includes a piercable membrane and contains a piercing mechanism;
• wherein the sliding member is slidable from a storage position to a ready position to a dispensing position;
• wherein, when the sliding member is in the storage position, moving the activation pin moves the sliding member from the storage position to the ready position, causing the sliding member to move toward the nozzle end, positioning the plunger end adjacent the dispensing chamber, and forcing a first face of the sliding member cam against an opposing first face of the angled cam on the button, forcing the button into a raised position, mixing the contents of the first and second dosage chambers and positioning a second face of the angled cam on the sliding member adjacent a second face on the angled cam on the button;
• and wherein, when the sliding member is in the ready position, pushing the firing button into the body forces the second face of the angled cam on the button to slide relative to the second face of the cam on the sliding member, forcing the plunger end into the dispensing chamber with a mechanical advantage relative to the force applied to the button, crushing the dispensing chamber against the piercing mechanism and dispensing the contents of the dosage form.