Photochemical tissue bonding
AssigneeThe General Hospital Corporation
InventorsBarbara Chan, Timothy Shane Johnson, Irene E. Kochevar, Mark Randolph, Robert W. Redmond, Jonathan M. Winograd
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Abstract
Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.
Claims24
1-43. (canceled)
A method for adhering blood vessel tissue in a subject, comprising:
- contacting an outer surface of a proximal vessel and an inner surface of a distal vessel with a photosensitizer agent;
- folding the distal vessel back to form a distal cuff;
- apposing the proximal vessel and the distal vessel;
- everting the distal cuff over the proximal vessel to form an overlap region;
- and applying electromagnetic energy to the tissue-photosensitizer complex in a manner effective to bond the tissues, thereby creating a tissue seal between the blood vessel tissue.
A method for adhering blood vessel tissue in a subject, comprising:
- placing a first blood vessel tissue and second blood vessel tissue in a conduit;
- contacting the first blood vessel tissue and second blood vessel tissue with at least one photosensitizer agent to form a tissue-photosensitizer complex;
- and applying electromagnetic energy to the tissue-photosensitizer complex in a manner effective to bond the tissues, thereby creating a tissue seal between the blood vessel tissues and the conduit.
Dependencies are inferred from the claim text.