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US 2013/0158296 A1Published application
Process for the synthesis of 1-amino-3-halo-4,6-dinitrobenzene
AssigneeE. I. Du Pont de Nemours and Company
InventorsAnnalisa Hargis, Joachim C. Ritter
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Abstract
A process is provided for the preparation of 1-amino-3-halo-4,6-dinitrobenzene and related compounds by monoamination of dihalodinitrobenzenes by ammonia in the presence of solvent and water. Using glycol as a solvent for the dihalodinitrobenzene and feeding ammonia at a rate at which it is consumed allows for the synthesis of high purity product, such as 1-amino-3-chloro-4,6-dinitrobenzene, at high yields.
Claims13
A process for preparing a compound represented by Formula (II):
- wherein Z is Cl or Br;
- R1 and R2 are each independently H, alkyl, or aryl;
- and R3 and R4, are each independently alkyl or aryl or may be joined to form an aliphatic ring structure;
- by forming a reaction mixture comprising a compound represented by the structure of the following Formula (III)
- and solvent, in the presence of ammonia and about 2 to about 25 wt % water, wherein the ammonia is fed at about the rate at which it is consumed;
- and heating the reaction mixture between about 60° C. and about 140° C. to convert the compound represented by the structure of Formula (III) to the compound represented by the structure of Formula (II).
3 more elements
Dependencies are inferred from the claim text.