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US 2013/0158271 A1Published application
Bivalent linkers and conjugates thereof
AssigneeEndocyte, Inc.
InventorsIontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Apparao SATYAM, Stephen J. HOWARD
Life of this patent
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Abstract
Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.
Claims6
A compound of the formula
- wherein
- n is an integer from 1 to about 4;
- Ra and Rb are each independently selected from the group consisting of hydrogen and alkyl, including lower alkyl such as C1-C4 alkyl that are optionally branched;
- or Ra and Rb are taken together with the attached carbon atom to form a carbocyclic ring;
- and
- X1 and X2 are each independently selected leaving groups, where each of said leaving groups is displaceable by an independently selected nucleophile.
3 more elements
A compound of the formula
- wherein
- m is an integer from 1 to about 4;
- and
- X1 and X2 are each independently selected leaving groups, where each of said leaving groups is displaceable by an independently selected nucleophile.
1 more element
The compound of claim 4 wherein the nucleophile is a drug, a vitamin, an imaging agent, a diagnostic agent, or another bivalent linker.
A compound of the formula
- wherein
- m is an integer from 1 to about 4;
- and
- X1 and X2 are each independently selected leaving groups, where each of said leaving groups is displaceable by an independently selected nucleophile.
1 more element
Dependencies are inferred from the claim text.