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US 2013/0158234 A1Published application
Specific binding agents of human angiopoietin-2
AssigneeAmgen Inc.
InventorsJonathan Daniel OLINER, Hosung Min
Life of this patent
Estimating the term…
Abstract
Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
Claims18
-117. (canceled)
A polypeptide capable of binding Ang-2, wherein the polypeptide comprises an amino acid sequence
- QKYQPLDELDKTLYDQFMLQQG
- [SEQ ID NO:
- 131]
- wherein up to two amino acids therein are substituted by an unconventional amino acid.
1 more element
A polypeptide capable of binding Ang-2, wherein the polypeptide comprises an amino acid sequence
- QKYQPLDELDKTLYDQFMLQQG
- [SEQ ID NO:
- 131]
- wherein up to two amino acids therein are substituted by a derivative amino acid.
1 more element
A specific binding agent, comprising a peptide of SEQ ID NO:
- 131 with up to 2 amino acid substitutions, wherein each of said amino acid substitutions is an unconventional amino acid substitution, wherein each unconventional amino acid substitution is an ε-acetyl lysine amino acid, and wherein said peptide comprising said substitutions specifically binds to Ang2.
A specific binding agent, comprising a peptide of SEQ ID NO:
- 131 wherein exactly one amino acid of said peptide of SEQ ID NO:
- 131 is a derivative amino acid, wherein said derivative peptide further comprises exactly one unconventional amino acid substitution, and wherein said peptide comprising said substitution specifically binds to Ang2.
Dependencies are inferred from the claim text.