Imbibing process for contact lens surface modification
AssigneeSemprus Biosciences Corp.
InventorsZheng ZHANG, Karen Ann SCHULTZ, Matt SKINNER, Christopher R. LOOSE
Life of this patent
Estimating the term…
Abstract
Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.
Claims23
A process for modifying the surface of a silicon-containing polymer, the process comprising the steps of:
- imbibing a zwitterionic monomer or a free radical initiator into a silicon-containing polymer in an imbibing mixture comprising the silicon-containing polymer, at least one of the zwitterionic monomer and the free radical initiator, and a solvent system;
- and
- polymerizing the zwitterionic monomer to modify the surface of the silicon-containing polymer with a zwitterionic polymer in a polymerization reaction mixture, the polymerization reaction mixture comprising the imbibed silicon-containing polymer, a solvent system and the zwitterionic monomer or the free radical initiator, the polymerization reaction mixture having a composition that differs from the composition of the imbibing mixture.
The process of claim 30 wherein X44 is —O(CH2)2N+(CH3)2(CH2)3SO3, —O(CH2)2N+(CH3)2(CH2)2CO2, —NH(CH2)2N+(CH3)2(CH2)3SO3, —NH(CH2)2N+(CH3)2(CH2)2CO2, —NH(CH2)3N+(CH3)2(CH2)3SO3, —NH(CH2)3N+(CH3)2(CH2)2CO2, —O(CH2)2N+(CH2CH3)2(CH2)3SO3, —O(CH2)2N+(CH2CH3)2(CH2)2CO2, —O(CH2)2N+(CH2CH2CH2CH3)2 (CH2)3SO3, —O(CH2)2N+(CH2CH2CH2CH3)2(CH2)2CO2 or —NH(CH2)3Ncyclo-(CH2)3SO3 and Ncyclo- is a heterocyclic structure or a heterocyclic derivative containing at least one nitrogen atom
A process for modifying the surface of a silicon-containing polymer, the process comprising the steps of:
- imbibing a zwitterionic monomer into a silicon-containing polymer in an imbibing mixture comprising the silicon-containing polymer, the zwitterionic monomer, and a solvent system;
- and
- polymerizing the zwitterionic monomer to modify the surface of the silicon-containing polymer with a zwitterionic polymer in a polymerization reaction mixture comprising the imbibed silicon-containing polymer, a free radical initiator and a solvent system wherein the polymerization reaction mixture has a composition that differs from the composition of the imbibing mixture.
Dependencies are inferred from the claim text.