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US 2013/0158150 A1Published application
Multistep uv process to create surface modified contact lenses
AssigneeSemprus Biosciences Corp.
InventorsZheng ZHANG, Alonzo COOK, Karen Ann SCHULTZ, Jun LI, Christopher R. LOOSE, Arthur COURY
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Abstract
Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.
Claims20
A process for modifying the surface of a silicon-containing polymer, the process comprising the steps of:
- forming a silicon-containing polymer containing a photo-initiator in a first polymerization reaction mixture, in which the photo-initiator initiates the polymerization and/or crosslinking of the silicon-containing polymer;
- forming a second polymerization reaction mixture comprising the silicon-containing polymer, a polymerization monomer, a free radical initiator system and a solvent system, the polymerization monomer comprising a zwitterionic monomer, wherein no more than 25% of the photo-initiator contained by the silicon-containing polymer is removed from the silicon-containing polymer before the silicon-containing polymer is combined with the solvent system of the second polymerization reaction mixture;
- and
- polymerizing the monomer in the second polymerization reaction mixture to form a surface modification on the surface of the silicon-containing polymer.
1 more element
A process for modifying the surface of a silicon-containing polymer, the process comprising the steps of:
- forming a silicon-containing polymer in a first polymerization reaction mixture, the first polymerization reaction mixture comprising a photo-initiator whereby the photo-initiator initiates the polymerization and/or crosslinking of the silicon-containing polymer;
- forming a second polymerization reaction mixture comprising the silicon-containing polymer, a polymerization monomer, a free radical initiator system and a solvent system, the polymerization monomer comprising a zwitterionic monomer, wherein no additional photo-initiator is added to the silicon-containing polymer before the silicon-containing polymer is combined with the solvent system of the second polymerization reaction mixture;
- and
- polymerizing the monomer in the second polymerization reaction mixture to form a surface modification polymer on the surface of the silicon-containing polymer.
1 more element
A process for modifying the surface of a silicon-containing polymer, the process comprising the steps of:
- forming a silicon-containing polymer in a first polymerization reaction mixture, the first polymerization reaction mixture comprising a photo-initiator whereby the photo-initiator initiates the polymerization and/or crosslinking of the silicon-containing polymer;
- forming a second polymerization reaction mixture comprising the silicon-containing polymer, a polymerization monomer, a free radical initiator system and a solvent system, the polymerization monomer comprising a zwitterionic monomer, wherein a residual amount of the photo-initiator that initiated the formation of the silicon-containing polymer in the first reaction mixture is present in the silicon-containing polymer when the silicon-containing polymer is combined with the solvent system of the second polymerization reaction mixture;
- and
- polymerizing the monomer in the second polymerization reaction mixture to form a surface modification polymer on the surface of the silicon-containing polymer.
1 more element
A process for modifying the surface of a silicon-containing polymer, the process comprising the steps of:
- forming a silicon-containing polymer in a first polymerization reaction mixture, the first polymerization reaction mixture comprising two or more unique photo-initiators whereby a first photo-initiator initiates the polymerization and/or crosslinking of the silicon-containing polymer;
- forming a second polymerization reaction mixture comprising the silicon-containing polymer, a polymerization monomer, a free radical initiator system and a solvent system, the polymerization monomer comprising a zwitterionic monomer, wherein a second photo-initiator is present in the silicon-containing polymer when the silicon-containing polymer is combined with the solvent system of the second polymerization reaction mixture;
- and
- polymerizing the monomer in the second polymerization reaction mixture to form a surface modification polymer on the surface of the silicon-containing polymer.
1 more element
Dependencies are inferred from the claim text.