Compositions and Methods for Depleting Mutant p53
AssigneeGeorgetown University
InventorsFung-Lung Chung, Anthony Di Pasqua
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Abstract
The invention is directed towards methods of treating abnormal tissues in a subject or sensitizing an abnormal tissue to a chemotherapeutic agent. The methods comprise screening at least a portion of an abnormal tissue for at least one mutant form of p53 protein, and administering at least one isothiocyanate (ITC) to the subject or abnormal tissue if the abnormal tissue is positive for the at least one mutant form of p53.
Claims22
A method of treating an abnormal tissue in a subject, the method comprising
- a) screening at least a portion of the abnormal tissue for at least one mutant form of p53 protein, and
- b) administering at least one isothiocyanate (ITC) to the subject if the abnormal tissue is positive for the at least one mutant form of p53.
A method of altering the three-dimensional conformation of a mutant p53 protein, the method comprising administering at least one isothiocyanate (ITC) to the mutant p53 protein to alter the three-dimensional conformation of the mutant p53 protein.
Dependencies are inferred from the claim text.