Therapeutic compositions
AssigneeLEO Laboratories Limited
InventorsMarc Barry Brown, Michael Crothers, Tahir Nazir
Life of this patent
Estimating the term…
Abstract
Ingenol angelate is a potent anticancer agent, and can be stabilised by dissolving it in an aprotic solvent in the presence of an acidic buffer.
Claims25
-46. (canceled)
A method of treating skin cancer in a subject in need thereof, the method comprising topically administering a therapeutically effective amount of a pharmaceutical formulation of ingenol angelate to the skin of the subject, wherein the pharmaceutical formulation comprises ingenol angelate in an amount from about 0.001% to about 0.15% w/w, and wherein at least about 99% of the ingenol angelate is ingenol-3-angelate (isoform ‘b’) and the pharmaceutical formulation has a pH of less than 4.
A method of treating a cancerous skin condition in a subject in need thereof, the method comprising topically administering a therapeutically effective amount of a pharmaceutical formulation of ingenol angelate to the skin of the subject, wherein the pharmaceutical formulation comprises ingenol angelate in an amount from about 0.001% to about 0.15% w/w, and wherein at least about 99% of the ingenol angelate is ingenol-3-angelate (isoform ‘b’) and the pharmaceutical formulation has a pH of less than 4.
Dependencies are inferred from the claim text.