Conformation-selective nucleic acid inhibitors of ampa glutamate receptors
AssigneeThe Research Foundation for The State University of New York
InventorsLi NIU, Zhen HUANG
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Abstract
The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
Claims20
A synthetic nucleic acid that binds to an open-channel conformation of a glutamate ion channel receptor, said nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 7.
(canceled)
11-12. (canceled)
14-20. (canceled)
An isolated DNA that codes for an RNA wherein the RNA comprises the nucleotide sequence of SEQ ID NO:
- 7.
27-28. (canceled)
Dependencies are inferred from the claim text.