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US 2013/0158089 A1Published application
MANUFACTURE, COMPOSITIONS AND USES OF COAGULATION FACTOR VIIa MODULATOR
AssigneePharmacyclics, Inc.
InventorsDavid Loury, Tarak Mody
Life of this patent
Estimating the term…
Abstract
Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I:
Claims11
-176. (canceled)
A composition comprising:
- a) a compound of Formula I or a salt thereof:
- and
- b) a thrombin modulator.
A composition comprising:
- a compound of Formula I or a salt thereof:
- wherein the composition is stable with respect to compound degradation for at least about 1 month.
A composition comprising:
- a) a compound of Formula I or a salt thereof:
- and
- b) an amino acid buffer.
A combined dosage comprising:
- a) a compound of Formula I or a salt thereof:
- and
- b) an additional therapeutic agent.
A composition comprising:
- a compound of Formula I or a salt thereof:
- wherein the pH of the composition is between 7 and 9.
A composition comprising:
- a) a compound of Formula I or a salt thereof:
- and
- b) a divalent cation.
A composition comprising:
- a compound of Formula I or a salt thereof:
- wherein the composition is formulated for administration by IV bolus or IV infusion.
A composition comprising:
- a compound of Formula I or a salt thereof:
- wherein the osmolality of the composition is from about 280 mOsm/kg to about 320 mOsm/kg.
A kit comprising,
- a) a container comprising:
- i. a compound of Formula I or a salt thereof:
- and
- ii. an additional therapeutic agent;
- and
- iii. a buffer and/or diluent;
- and
- b) a set of instructions.
5 more elements
A composition comprising:
- a compound of Formula I or a salt thereof:
- wherein the composition is isotonic.
Dependencies are inferred from the claim text.