Tg2 inhibitors and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsKapil Mehta, Anupam Kumar, Jansina Fok, Shuxing Zhang
Life of this patent
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Abstract
Methods and compounds for treating cancer, dmg resistance and/or metastasis are described herein. These methods and compounds can inhibit the expression of aberrant TG2 expression and/or inhibit the binding of GTP to TG2, and thereby prevent the induction of epithelial to mesenchymal transition of cancer cells, and a stem cell-like phenotype.
Claims8
A method of treating drug resistance in a subject in need thereof comprising the step of administering to the subject a therapeutic amount of a compound of the structural Formula I
- wherein R1, R2, R3 and R4 are each independently hydrido, halo, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, carbamoyl, nitro, cyano, perfluoroalkyl, trifluoromethylalkyl, hydroxyl, thiol, hydroxycarbonyl, or alkylcarbonyl.
A method of treating drug resistance in a subject in need thereof comprising the step of administering to the subject a therapeutic amount of a compound of the structural Formula II
- wherein R5 is H or methyl, and R7, R7, R8 and R9 are independently selected from hydrido, halo, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, carbamoyl, nitro, cyano, perfluoroalkyl, trifluoromethylalkyl, hydroxyl, thiol, hydroxycarbonyl, alkylcarbonyl, or may constitute a 5- or 6-membered heterocyclic ring containing one or two oxygen atoms.
A method of treating drug resistance in a subject in need thereof comprising the step of administering to the subject a therapeutic amount of a compound of the structural Formula III
- wherein R10, R11, R12 and R13 are independently selected from hydrido, halo, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, carbamoyl, nitro, cyano, perfluoroalkyl, trifluoromethylalkyl, hydroxyl, thiol, hydroxycarbonyl, or alkylcarbonyl.
A compound useful in treating metastasis of cancer cells wherein the compound is of the structural formula, Formula I:
- wherein R1, R2, R3 and R4 are each independently hydrido, halo, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, carbamoyl, nitro, cyano, perfluoroalkyl, trifluoromethylalkyl, hydroxyl, thiol, hydroxycarbonyl, or alkylcarbonyl.
A compound useful in treating metastasis of cancer cells wherein the compound is of the structural formula, Formula II
- wherein R5 is H or methyl, and R7, R7, R8 and R9 are independently selected from hydrido, halo, alkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, carbamoyl, nitro, cyano, perfluoroalkyl, trifluoromethylalkyl, hydroxyl, thiol, hydroxycarbonyl, alkylcarbonyl, or may constitute a 5- or 6-membered heterocyclic ring containing one or two oxygen atoms.
A compound useful in treating metastasis of cancer cells wherein the compound is of the structural formula, Formula III
- wherein R10, R11, R12 and R13 are independently selected from hydrido, halo, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, carbamoyl, nitro, cyano, perfluoroalkyl, trifluoromethylalkyl, hydroxyl, thiol, hydroxycarbonyl, or alkylcarbonyl.
Dependencies are inferred from the claim text.