Heterocyclic compounds as dgat1 inhibitors

A compound of formula 1:

• or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or N-oxide thereof;
• wherein,
• Z is selected from:
• indicates the point of attachment;
• n is an integer selected from 1-5;
• m is 0 or 1;
• R1 and R2 are independently selected from hydrogen or (C1-C12)-alkyl, or R1 and R2 can optionally form an unsubstituted or substituted (C3-C7) cycloalkyl ring;
• R3 is hydrogen or (C1-C12)-alkyl;
• R5 is selected from hydrogen, (C1-C12)-alkyl, CF3, (C3-C7)-cycloalkyl, aryl, or heterocyclyl,
• B is a 5-membered heteroaryl ring represented by any one of the general structures (i) to (x);
• wherein 1 and 2 are the points of attachment of B to phenyl and to Z respectively and R4 is selected from hydrogen, (C1-C12)-alkyl or aryl;
• or
• B is a 6-membered heteroaryl ring containing 1 or 2 N-atoms, wherein the 6-membered heteroaryl ring may be unsubstituted or substituted with one or more groups selected from halogen, hydroxy, (C1-C12)-alkoxy, cyano, nitro, (C1-C12)-alkyl, (C2-C12)-alkenyl, (C2-C12)-alkynyl, (C3-C12)-cycloalkyl, aryl, aryloxy, heterocyclyl or O-heterocyclyl;
• L is selected from *NHC(O)NH, *N(CH3)C(O)NH *NHC(S)NH, *SO2NH, *CONH or *NH(C═NR6)NH, wherein * indicates the point of attachment of L to A, and R6 is selected from hydrogen, methyl, cyano or nitro;
• A is selected from (C1-C12)-alkyl, (C3-C12)-cycloalkyl, aryl or heterocyclyl;
• wherein,
• (C1-C12)-alkyl is unsubstituted or substituted with one or more groups selected from halogen, hydroxy, (C1-C12)-alkoxy, cyano, nitro, (C3-C12)-cycloalkyl, aryl, heterocyclyl, C(O)Rp, C(O)ORp, NRpRq, C(O)NRpRq, SRp, S(O)Rp or SO2Rp;
• (C3-C12)-cycloalkyl is unsubstituted or substituted with one or more groups selected from halogen, hydroxy, (C1-C12)-alkoxy, cyano, nitro, aryl, heterocyclyl, C(O)Rp C(O)ORp, NRpRq, C(O)NRpRq, SRp, S(O)Rp or SO2Rp;
• aryl is unsubstituted or substituted with one or more groups selected from halogen, hydroxy, (C1-C12)-alkoxy, cyano, nitro, (C1-C12)-alkyl, OCF3, CF3, (C2-C12)-alkenyl, (C2-C12)-alkynyl, (C3-C12)-cycloalkyl, aryl, aryloxy, heterocyclyl, O-heterocyclyl, C(O)Rp, C(O)ORp, NRpRq, C(O)NRpRq, SRp, S(O)Rp or SO2Rp;
• or aryl may be fused with an unsubstituted or substituted 5- or 6-membered cycloalkyl ring optionally containing one or more heteroatoms selected from O, N or S;
• heterocyclyl is unsubstituted or substituted with one or more groups selected from halogen, hydroxy, (C1-C12)-alkoxy, cyano, nitro, (C1-C12)-alkyl, (C2-C12)-alkenyl, (C2-C12)-alkynyl, (C3-C12)-cycloalkyl, aryl, aryloxy, heterocyclyl, O-heterocyclyl, C(O)Rp, C(O)ORp, NRpRq, C(O)NRpRq, SRp, S(O)Rp or SO2Rp;
• Rp and Rq are independently selected from hydrogen, (C1-C12)-alkyl, aryl, aralkyl or heterocyclyl, or Rp and Rq together with the N to which they are attached optionally form a 3- to 7-membered ring;
• with a proviso that A is not a methyl group.