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US 2013/0158068 A1Published application
Dicarboximide derivatives of berbamine, the preparation and use thereof
AssigneeHangzhou Bensheng Pharmaceutical Co., Ltd.
InventorsRongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai
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Abstract
The present invention relates to a novel dicarboximide derivative of berbamine represented by formula I, including, but not limited to, a phthalimide derivative of berbamine and an aromatic heterocyclic dicarboximide derivative of berbamine, or a pharmaceutically acceptable salt thereof, to a process for preparation of the same, to a pharmaceutical composition comprising said compound and to use thereof in manufacture of an antitumor medicament.
Claims19
A dicarboximide derivative of berbamine of formula (I):
- wherein, R1 is selected from H, halogen, amino, nitro, cyano, hydroxyl, mercapto, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C1-C6 alkylthio, substituted or unsubstituted C1-C6 alkylamino, substituted or unsubstituted C3-C7 cycloalkyl;
- A is selected from a linear or branched, substituted or unsubstituted alkylene —(CH2)n—, optionally being interrupted by a heteroatom selected from the group consisting of O, N, S, wherein n is an integer from 1 to 15;
- W, X, Y and Z are selected from substituted or unsubstituted methine CH, methylene CH2 and a heteroatom selected from the group consisting of O, N and S, wherein at least two of W, X, Y and Z are CH or CH2;
- wherein “substituted” means a substitution by a sub stituent selected from the group consisting of halogen, amino, nitro, cyano, hydroxyl and mercapto;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.