TRPV1 Antagonists

A compound of formula (I):

• or a salt thereof, wherein:
• L is a bond or CH2, and is bound to any one of the carbon atom of the monocyclic ring containing X1;
• X1 is CH2, O, or N(Rw) wherein Rw is hydrogen, alkyl, or haloalkyl;
• n is 1, 2, or 3;
• A is CH or N;
• m is 0, 1, 2, 3, or 4;
• Rx, at each occurrence, represents optional substituent on any substitutable carbon atom of the ring containing A and each Rx is independently alkyl, halogen, haloalkyl, OH, O(alkyl), O(haloalkyl), NH2, N(H)(alkyl), or N(alkyl)2;
• p is 0, 1, 2, 3, 4, 5, or 6;
• Ry, at each occurrence, represents optional substituent on any substitutable carbon atom of the ring containing X1 and each Ry is independently alkyl, haloalkyl, —(C1-C6 alkylenyl)-O(alkyl), G1, and —(C1-C6 alkylenyl)-G1;
• wherein G1, at each occurrence, is independently an aryl, optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, O(alkyl), and O(haloalkyl);
• two Ry groups that are attached to the same carbon atom, together with said carbon atom to which they are attached, optionally form a C3-C6 monocyclic cycloalkyl ring, wherein the monocyclic cycicoalkyl ring is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of alkyl, oxo, halogen, and haloalkyl;
• is 0 or 1;
• The alphabets a and b on the bicyclic ring independently represent the positions at which the —NH— of the urea moiety and a carbon atom of the ring are bound to each other,
• provided that when s is 1, the binding position for —NH— is at position a;
• and when s is 0, the binding position for —NH— is at position b;
• Rz, at each occurrence, represents optional substituent on any substitutable position of the bicyclic ring and is independently halogen, haloalkyl, or alkyl;
• and
• q is 0, 1, 2, or 3.