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US 2013/0158066 A1Published application
4-azaindole inhibitors of crac
AssigneeHoffmann-La Roche Inc.
InventorsMuzaffar Alam, Daisy Jo Du Bois, Ronald Charles Hawley, Ana Elena Minatti, Joshua Kennedy-Smith, Kshitij Chhabilbhai Thakkar, Robert Stephen Wilhelm
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Abstract
Disclosed are compounds of Formula (I): useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.
Claims10
A compound of Formula (I):
- wherein:
- Ar is phenyl, unsubstituted or substituted with one, two or three substituents independently selected from halogen and alkoxy;
- and
- Ar′ is phenyl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl, haloalkyl, —SO2N(CH3)2, —CN and halogen, or heteroaryl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl, haloalkyl and halogen,
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.