Novel iso-ergoline derivatives

A compound of Formula (I) or (II):

• or ion pairs, metabolites, polymorphs, salts, hydrates or solvates thereof, wherein:
• R1 is hydrogen, (C1-C4) alkyl, substituted (C1-C4) alkyl or (C1-C4) alkyl substituted with one or more fluorine atoms;
• R2 is alkyl, substituted alkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, —NO2, —N3, —OH, —S(O)kR100, —OR101, —NR102R103, —CONR104R105, —CO2R106 or —O2CR107;
• R3 is hydrogen, (C1-C3) alkyl, (C1-C3) substituted alkyl or (C1-C3) alkyl substituted with one or more fluorine atoms;
• R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, —OR108, —NR109R110,
• R5 is (C1-C4) alkyl or (C1-C4) substituted alkyl;
• R6 is hydrogen, (C1-C4) alkyl, substituted (C1-C4) alkyl, benzyl or substituted benzyl;
• R7 is C1-C4) alkyl, substituted (C1-C4) alkyl, benzyl or substituted benzyl;
• R8 is hydrogen, OH, ═O, (C1-C4) alkyl, (C1-C4) substituted alkyl, —CO2R114 or —CONR115R116;
• R9 is hydrogen, OH, ═O, (C1-C4) alkyl, (C1-C4) substituted alkyl, —CO2R117 or —CONR118R119;
• R10 is hydrogen, OH, ═O, (C1-C4) alkyl, (C1-C4) substituted alkyl, —CO2R120 or —CONR121R122;
• R11 is hydrogen, (C1-C3) alkyl or (C1-C3) alkyl substituted with one or more fluorine atoms;
• R12 is hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —S(O)mR111 or —CONR112R113;
• R100-R122 are independently hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
• m and k are independently 0, 1 or 2;
• n is 0, 1, 2 or 3;
• and
• provided that when R11 is hydrogen or (C1-C3) alkyl, R1 is (C1-C4) alkyl substituted with one or more fluorine atoms;
• and R109 and R110 are not substituted with fluorine unless R12 is acyl or substituted acyl.