Pyrimidine classical cannabinoid compounds and related methods of use

A method of treating cancer mediated by a cannabinoid receptor comprising contacting said receptor with a compound in an amount to treat said cannabinoid receptor-mediated disorder, wherein the compound is of the formula

• wherein
• represents an optional double bond wherein the ring that optionally contains it is selected from hexahydro, 6a,10a-dehydro, 8,9-dehydro, and 9,10-dehydro;
• ----- Y is selected from S, O, CH2, CH(CH3), CH(OH), C(CH3)(OH), C(CH3)2, C(—U(CH2)nU—), C(O), NH, S(O), and S(O)2;
• n is an integer ≧1;
• U is selected from CH2, S, and O;
• Z is selected from H, substituted and unsubstituted alkyl, and
• cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl, wherein each alkyl portion is optionally substituted and the ring portion of each is optionally substituted with one, two, three, four or five substituents;
• and
• R1 is selected from H and substituted and unsubstituted alkyl.