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US 2013/0158049 A1Published application
7-azaindole inhibitors of crac
AssigneeHoffmann-La Roche Inc.
InventorsMuzaffar Alam, Daisy Joe Du Bois, Ronald Charles Hawley, Niala Bhagirath, Joshua Kennedy-Smith, Robert Stephen Wilhelm
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Abstract
Disclosed are compounds of Formula (I): useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.
Claims16
A compound of Formula (I):
- wherein:
- Ar is
- phenyl, unsubstituted or mono- or bi-substituted independently with halogen,
- heteroaryl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl and halogen, or
- unsubstituted cycloalkyl;
- and
- Ar′ is
- phenyl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl, —C(O)OCH3, —SO2N(CH3)2, —CN and alkoxy,
- heteroaryl, unsubstituted or substituted with one or two substituents independently selected from lower alkyl, heteroaryl, —C(O)NHCH3, —C(O)NH(CH2)2OH, —SO2CH3 and haloalkyl,
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.