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US 2013/0158040 A1Published application
Diazaindole inhibitors of crac
AssigneeHoffmann-La Roche Inc.
InventorsMuzaffar Alam, Niala Bhagirath, Daisy Joe Du Bois, Ronald Charles Hawley, Ana Elena Minatti, Joshua Kennedy-Smith, Robert Stephen Wilhelm
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Abstract
Disclosed are compounds of Formula (I): useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.
Claims15
A compound of Formula (I):
- wherein:
- one of X or Y is C and the other is N;
- Ar is unsubstituted cycloalkyl, unsubstituted phenyl or phenyl mono- or bi-substituted independently with halogen;
- Ar′ is—phenyl, unsubstituted or mono- or bi-substituted independently with —SO2N(CH3)2, lower alkyl or —C(O)OCH3, or
- heteroaryl, unsubstituted or mono- or bi-substituted independently with lower alkyl or haloalkyl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.