Use of sigma ligands in opioid-induced hyperalgesia
AssigneeLaboratorios Del Dr. Esteve, S.A.
InventorsJosé Miguel Vela Hernández, Daniel Zamanillo-Castanedo, Margarita Puig Riera de Conias
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Abstract
The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat opioid-induced hyperalgesia (OIH) associated to opioid therapy.
Claims21
1-12. (canceled)
A method of treatment and/or prophylaxis of a patient suffering from or being susceptible to opioid-induced hyperalgesia associated to opioid therapy, the method comprising administering to the patient in need of such treatment or prophylaxis a therapeutically effective amount of a sigma ligand.
A method of treatment and/or prophylaxis of a patient suffering from or being susceptible to opioid-induced hyperalgesia associated to opioid therapy, the method comprising administering to the patient in need of such a treatment or prophylaxis a therapeutically effective amount of a combination of at least one sigma ligand and at least one opioid or opiate compound, wherein said at least one sigma ligand and at least one opioid or compound are administered simultaneously, separately, or sequentially to the patient in need of such a treatment or prophylaxis.
Dependencies are inferred from the claim text.