Alkyne-bridged hetero-aromatics and uses thereof

A compound having the following Formulae, or a pharmaceutical acceptable salt thereof:

• wherein X1 and X2 are each independently C or N;
• Y1, Y2 and Y3 are each independently C or N;
• each Het1 is independently aryl or 3-7-membered heterocycle containing at least one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur, in which said aryl may be optionally substituted by one to three R1 and one R2, and said heterocycle may be optionally substituted by one to three R1;
• each Het2 is independently 3-7-membered heterocycle containing at least one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur, in which said heterocycle may be optionally substituted by one R5 and one to three R6;
• each R1 is independently H, halogen, OH, CN, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, (C1-C6)alkylthio, NRaRb, or haloalkyl (e.g., CF3);
• each R2 is independently H, OH, CN, or NRaRb;
• each R5 is independently H, (C1-C4)alkyl, (C3-C7)cycloalkyl, (C1-C6)haloalkyl (e.g., CF3), (CH2)nORa, or (CH2)nNRaRb;
• each R6 is independently H, halogen, OH, CN, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, (C1-C6)alkylthio, NRaRb, (C1-C6)haloalkyl (e.g., CF3), (CH2)nORa, (CH2)nSRa, (CH2)nNRaRb, (CH2)n(C1-C6)haloalkyl;
• R7 and R8 are each independently H, halogen, OH, CN, OCF3, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C3-C7)cycloalkyl, 3-7-membered heterocycle, (C1-C6)alkylthio, NRaRb, (C1-C6)haloalkyl (e.g., CF3), (CH2)n(C3-C7)cycloalkyl, (CH2)nORa, (CH2)nSRa, (CH2)nNRaRb, or (CH2)n(C1-C6)haloalkyl, in which said heterocycle contains at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and may be optionally substituted by from one to three groups which may be the same or different selected from the group consisting of halogen, OH, CN, (C1-C4)alkyl, (C1-C4)haloalkyl (e.g., CF3) and (C1-C4)alkoxy;
• each occurrence of Ra and Rb is independently hydrogen or (C1-C6)alkyl, or Ra and Rb, together with the nitrogen atom to which they are attached, form a saturated or unsaturated heterocyclic ring containing from three to seven ring atoms, which ring may optionally contain another heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and may be optionally substituted by from one to three groups which may be the same or different selected from the group consisting of (C1-C4)alkyl, phenyl and benzyl;
• n is 1-6;
• and
• m is 1-3.