Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof

A pyrrolyl substituted dihydroindol-2-one derivative of formula I, a pharmaceutically acceptable salt thereof, a solvate of said derivative, or a solvate of said salt,

• wherein,
• R1 is selected from the group consisting of hydrogen atom, C1-4 alkyl;
• R2 is selected from the group consisting of C1-4 alkyl, C1-4 alkyl substituted with one or more halogen or hydroxyl groups, allyl, propargyl, —(CH2)mNR11R12, —SOjR11, —(CH2)mSOj(CH2)nNR11R12, —CO(CH2)kNR11R12, —SOj(CH2)mCH═CH(CH2)nNR11R12, —CO(CH2)mCH═CH(CH2)nNR11R12;
• wherein R11 and R12 are each independently selected from the group consisting of hydrogen atom, C1-4 alkyl, cycloalkyl, heterocycloalkyl, wherein said cycloalkyl, heterocycloalkyl can be substituted with one or more halogen, alkyl, hydroxy, amino, alkoxy groups;
• or R11, R12 together with N atom can form a 4- to 8-membered heterocycle, the heterocycle can further comprise 0 to 2 heteroatoms selected from N, S, O, and the heterocycle can be substituted at any other positions, except S or O atom, and the substituent is selected from the group consisting of C1-4 alkyl, hydroxy-substituted C1-4 alkyl, —(CH2)mNR11R12;
• m, n each independently can be an integer of 0 to 4, k is an integer of 1 to 4, and j is 1 or 2;
• R3, R4 are each independently selected from the group consisting of hydrogen atom, halogen, C1-4 alkyl;
• R5, R6, R7, R8 are each independently selected from the group consisting of hydrogen atom, halogen, C1-4 alkyl, C1-4 alkyl substituted with one or more halogens, C1-4 alkoxy, alkoxy substituted with one or more halogens, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, hydroxy, —NR9R10, —SOR9, —SO2R9, —NR9SO2R10, —SO2NR9R10, —COR9, —NR9COR10, —OCOR9, —CN, —NO2, wherein the aryl, heteroaryl, cycloalkyl groups can be further substituted at any positions with alkyl, halogen or haloalkyl, alkoxy, haloalkoxy;
• R9 and R10 are each independently selected from the group consisting of hydrogen atom, C1-4 alkyl, C1-4 alkyl substituted with one or more halogens, cycloalkyl, aryl or heteroaryl, wherein the cycloalkyl, aryl or heteroaryl can be substituted with one or more halogens, alkyl, hydroxy, amino, or haloalkyl, alkoxy, haloalkoxy;
• the above halogens can be independently selected from the group consisting of fluorine, chlorine and bromine.