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US 2013/0158029 A1Published application
Sigma receptor inhibitors
AssigneeLaboratorios Del Dr. Esteve, S.A.
InventorsMonica Garcia López, Antoni Torrens Jover, José Luis Diaz Fernández, Ana Maria Caamaño Moure
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Abstract
The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
Claims20
A compound of general formula (I):
- wherein
- R1 represents substituted or unsubstituted, aromatic or non-aromatic heterocyclyl;
- substituted or unsubstituted aryl;
- or substituted or unsubstituted cycloalkyl;
- R2 and R3, identical or different, represent a hydrogen atom;
- F;
- Cl;
- Br;
- I;
- CF3;
- OH;
- SH;
- NH2;
- CN;
- substituted or unsubstituted alkyl;
- substituted or unsubstituted alkenyl;
- substituted or unsubstituted alkoxy;
- substituted or unsubstituted cycloalkyl;
- substituted or unsubstituted aryl;
- substituted or unsubstituted, aromatic or non-aromatic heterocyclyl;
- substituted or unsubstituted cycloalkylalkyl;
- substituted or unsubstituted arylalkyl;
- substituted or unsubstituted, aromatic or non-aromatic heterocyclylalkyl;
- a (C═O)—R7 group;
- a (C═O)—O—R8 group;
- a S(O)t—R9 group;
- or a (C═)—NR10R11 group;
- R4 and R5, identical or different, represent a hydrogen atom;
- substituted or unsubstituted alkyl;
- substituted or unsubstituted alkenyl;
- substituted or unsubstituted alkoxy;
- substituted or unsubstituted cycloalkyl;
- substituted or unsubstituted aryl;
- substituted or unsubstituted, aromatic or non-aromatic heterocyclyl;
- substituted or unsubstituted cycloalkylalkyl;
- substituted or unsubstituted arylalkyl;
- substituted or unsubstituted, aromatic or non-aromatic heterocyclylalkyl;
- a (C═O)—R7 group;
- a (C═O)—O—R8 group;
- a S(O)t—R9 group;
- or a (C═O)—NR10R11 group;
- or
- together form, with the nitrogen atom to which they are attached, a substituted or unsubstituted, aromatic or non-aromatic heterocyclyl group;
- X represents an oxygen atom or a CH—R12 group wherein R12 is selected from H, CH3, SH, OH, NH2, CF3, Cl, F, Br, I, and CN;
- m is 1, 2, 3 or 4;
- n is 1, 2, 3 or 4;
- t is 1, 2 or 3;
- and
- R7, R8, R9, R10 and R11, identical or different, represent a hydrogen atom;
- substituted or unsubstituted C1-6 alkyl;
- substituted or unsubstituted C2-6 alkenyl;
- substituted or unsubstituted C1-6 alkoxy;
- substituted or unsubstituted cycloalkyl;
- substituted or unsubstituted aryl;
- substituted or unsubstituted, aromatic or non-aromatic heterocyclyl;
- substituted or unsubstituted cycloalkylalkyl;
- substituted or unsubstituted arylalkyl;
- substituted or unsubstituted, aromatic or non-aromatic heterocyclylalkyl;
- or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.
56 more elements
Dependencies are inferred from the claim text.