Acrylamide Compounds And Use Thereof For Inhibiting Apoptosis

A compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof,

• wherein
• A represents ═S or —SR4;
• X represents F, Cl, Br or I;
• R1 represents thienyl or substituted thienyl;
• R2, R3 each individually represent hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkyl, amino C1-C6 alkyl, mono-substituted or di-substituted amino C1-C6 alkyl, phenyl C1-C6 alkyl, substituted phenyl C1-C6 alkyl, heterocyclic group C1-C6 alkyl, phenyl, substituted phenyl, heterocyclic group or substituted heterocyclic group, wherein R2 and R3 may be attached together to form a saturated cyclic alkyl, nitrogen- or oxygen-containing heterocyclic group;
• and
• R4 represents methyl, ethyl, propyl, isopropyl, butyl, or pentyl.

A compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof.

• wherein:
• A represents ═S or —SR4;
• X represents Cl;
• R1 represents 2-thienyl or 3-thienyl;
• R2, R3 each individually represent hydrogen, methyl, isopropyl, 2-methoxy ethyl, 3-isopropoxy propyl, 2-N,N-dimethyl ethyl, cyclohexyl, cycloheptyl, o-methoxy phenyl, o-fluorophenyl, o-chlorophenyl, p-chlorophenyl, benzyl or 8-quinolyl, wherein R2 and R3 may be attached together to form a piperidine ring, morpholine ring, or N-methyl piperazine ring;
• and
• R4 represents methyl or ethyl.