Indazole derivatives useful as erk inhibitors

A compound of Formula I

• or a pharmaceutically acceptable salt, solvate or ester thereof, wherein:
• R is H;
• R1 is selected from the group consisting of aryl, heterocyclyl and —C(═O)—NR5R6;
• R2 is H or alkyl;
• X is selected from the group consisting of —NR7, —C(R8)(R9)—, —O—, —S—, —S(═O)—, and —S(═O)2;
• each R3 independently is selected from the group consisting of alkyl, aryl, hydroxyl, and —S-alkyl, or wherein two R3 groups together with the same carbon atom to which both are attached form —C(═O)—;
• m is 0, 1, or 2;
• n is 0 or 1;
• R4 is selected from the group consisting of H, alkyl, aryl, —C(═O)-aryl, and —C(═O)—O-alkyl;
• R5, R6, and R7 independently are H or alkyl;
• R8 and R9 independently are H, alkyl or aryl;
• or —C(R8)(R9)— together is heterocyclyl.