Back to results
US 2013/0158013 A1Published application
Processes for the preparation of 5-ht2c receptor agonists
AssigneeArena Pharmaceuticals, Inc.
InventorsAnthony C. Blackburn, Anna Shifrina
Life of this patent
Estimating the term…
Abstract
Processes and intermediates for preparing salts of the 5-HT2C-receptor agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, and pharmaceutically acceptable solvates and hydrates thereof, that are useful for, inter alia, weight management.
Claims32
A process for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt hemihydrate Form III, comprising slurrying a first mixture comprising:
- (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt Form IV;
- and a first solvent;
- to form said (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt hemihydrate Form III.
A salt which is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride salt Form IV.
-50. (canceled)
Dependencies are inferred from the claim text.