Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same
AssigneeKemPharm, Inc.
InventorsTravis Mickle, Sven Guenther, Sanjib Bera
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Abstract
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.
Claims23
A composition for treating a psychiatric disorder in a subject, comprising a prodrug conjugate of 2-(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol (quetiapine) and a straight chain, saturated fatty acid having the general formula of CnH2n+1—CO2H, wherein n is 1-7.
Dependencies are inferred from the claim text.