Pyrimidine derivatives as fak inhibitors

Compounds of the formula I

• in which
• R1 denotes (CH2)nAr1 or (CH2)nHet1,
• R2 denotes Ar2 or Het2,
• R3 denotes H, Hal, A, Het4 or CN,
• Ar1 denotes phenyl which is unsubstituted or mono-, di-, tri-, tetra or pentasubstituted by Hal, A, (CH2)nOH, (CH2)nOA, (CH2)nCN, NO2, SO2A, COOH, COOA, NH2, NHA, NA2, NHCH2Ar1, CHO, COA, (CH2)nCONH2, (CH2)nCONHA, (CH2)nCONA2, Het3, NHCOHet3, SO2NH2, SO2NHA and/or NHCOA,
• Ar2 denotes phenyl which is unsubstituted or mono-, di-, tri-, tetra or pentasubstituted by Hal, A, (CH2)nOH, (CH2)nOA, (CH2)nCN, NO2, SO2A, COOH, COOA, NH2, NHA, NA2, NHCH2Ar1, CHO, COA, (CH2)nCONH2, (CH2)nCONHA, (CH2)nCONA2, SO2NH2, NHSO2A, SO2NHA, NA′SO2A, C(R4R5)CN and/or NHCOA,
• Het1 denotes a mono- or bicyclic aromatic, unsaturated or saturated heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di-, tri- or tetrasubstituted by Hal, A, NH2, NHA, NA2, COOH, CN, NHCOA, CN, NHCOA, COA, OAr, COOA, CONH2, CONHA, CONA2, CONHAr and/or ═O,
• Het2 denotes a mono- or bicyclic aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di-, tri- or tetrasubstituted by Hal, A, NH2, NHA, NA2, COOH, COA, COOA, CONH2, CONHA, CONA2, CONHAr, C(R4R5)CN, NHSO2A, NASO2A, NHCOA, NA′COA, NACHO, NH(CH2)pNHCHO and/or ═O,
• Ar denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal and/or A,
• R4, R5 each, independently of one another, denote H or A,
• R4 and R5 together also denote alkylene having 2-5 C atoms, in which one CH2 group may be replaced by NH, NA', O or S,
• Het3 denotes a mono- or bicyclic aromatic, unsaturated or saturated heterocycle having 1 to 3 N, O and/or S atoms, which may be unsubstituted or mono- or disubstituted by A, NH2 and/or ═O,
• Het4 denotes a monocyclic aromatic heterocycle having 1 to 3 N, O and/or S atoms, which may be unsubstituted or mono- or disubstituted by A,
• A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7H atoms may be replaced by F and/or in which one or two non-adjacent CH and/or CH2 groups may be replaced by O, NH, NA′, S, SO, SO2 and/or by CH═CH groups,
• or
• cyclic alkyl having 3-7 C atoms,
• A′ denotes unbranched or branched alkyl having 1-6 C atoms,
• Hal denotes F, Cl, Br or I,
• n denotes 0, 1, 2, 3 or 4,
• p denotes 1, 2, 3 or 4,
• and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.